The most effective strategies for diagnosing and treating depressions with Imipramine

Nowadays, depression has become one of the most common diseases in the world. In terms of prevalence, it is quite comparable to cardiovascular diseases. Researchers call a different number of patients suffering from this disease. Even by the most conservative estimates, there are millions of people with depression in the world. There is also a specific figure: approximately 1/5 of the population is depressed. And, according to WHO experts, the number of patients suffering from depression will increase from year to year.

Depression can be caused by a high rate of modern life, instability, uncertainty in the future, competition, and migration processes. Depressed people belong to different social strata. This disorder doesn't divide people into rich and poor.

Timely treatment of depression usually leads to positive results. If depression is diagnosed in a timely manner, and treatment is carried out correctly, the patient can count on full recovery. Depression will not go into a severe form or reoccur. Today, the treatment of depression in Australia is carried out by means of complex methods. They combine drug and non-drug therapy, as well as psychotherapy. As a rule, medications called "antidepressants" are used to treat depression.

Antidepressants are psychotropic drugs used primarily to treat depression. In a depressed patient, they improve mood, reduce or relieve anguish, lethargy, apathy, anxiety and emotional stress, increase mental activity, normalize phase structure, sleep duration, and appetite.

General characteristics of antidepressants. The mechanism of action of antidepressants.

Currently, practical medicine uses a large number of antidepressants of different chemical structure, varying in pharmacological, neurochemical profile, and clinical features. According to some estimates, in 1997, at least 125 drugs with antidepressant activity were at various stages of study, and the search for new promising compounds continues. It should be borne in mind that about 30% of patients are resistant to treatment with antidepressants, which constantly stimulates the search for new drugs of this class.

Non-selective monoamine reuptake neuronal blockers

Tricyclic antidepressants

Tricyclic antidepressants (TCAs) or tricyclics is a group of highly effective antidepressants with much fewer side effects compared to MAOI. They don't require adherence to a special diet. Moreover, such medications don't impose large restrictions on the simultaneous use of other drugs, as well as low Tofranil cost of the treatment. The main side effect of tricyclic antidepressants is the anticholinergic effect, i.e., dry mouth, blurred vision, constipation, difficulty urinating, accommodation disturbances, increased intraocular pressure, and tachycardia. Other adverse effects of tricyclic antidepressants include cognitive impairment, sedation, weight gain, epileptic seizures, orthostatic hypotension, tremors, nausea, hypomania, and confusion; neurological disorders (extrapyramidal disorders, paresthesia and myoclonic twitches); adverse effects on the liver; long-term use or overdose can use cardiotoxic effects (arrhythmias, etc.)

Tofranil is one of the main representatives of tricyclic antidepressants.

major depression

The main active substance of the drug (Imipramine) is a tricyclic antidepressant, the main purpose of which is the treatment of depression, astheno-depressive syndrome, depression (endogenous, involutional, climacteric, reactive and alcoholic), as well as a number of other depressive states that accompany psychopathy and neurosis.

Tofranil pills have antidepressant, thymoleptic, psychostimulant pharmacological action. Since Tofranil price is low, it is widely used in the treatment of the following diseases and disorders:

  • complex psychopathological conditions caused by the use of opioids, sedatives, and hypnotics;
  • various manifestations of schizoaffective disorder;
  • depression episodes;
  • agoraphobia;
  • episodic manifestations of panic disorders;
  • generalized anxiety disorder;
  • obsessive-compulsive disorder;
  • active stress response;
  • deviations in adaptive reactions;
  • anorexia nervosa;
  • bulimia nervosa;
  • increased drowsiness in the absence of organic damage and disorders;
  • inorganic enuresis.

The mechanism of Imipramine action

By its chemical nature, Imipramine is a tertiary amine that acts on a variety of neurotransmitter systems, known for their involvement in the etiology of depression, anxiety, enuresis, and many other mental disorders. Generic Tofranil has the same structure as some muscle relaxants. It also has a significant analgesic effect and, thus, is very effective in some similar painful conditions.

Tofranil without prescription is administered internally, intramuscularly, and intravenously. The usual dose is 0.75–0.1 g (75–100 mg) per day, with a gradual daily increase by 0.025 g to 200–300 mg per day. In case of severe depressions treated in the hospital, combination therapy is used (intramuscular and intravenous administration and the drug in pills). If the psychiatrist considers it suitable, the treatment with Tofranil online can be started from the shock doses (0.1–0.15 g). The average duration of treatment is 4–6 weeks, with a gradual decrease in the dose by 0.025 g every 2–3 days and a switch to maintenance therapy.

Elderly people and children require smaller doses of the drug. During the treatment with cheap Tofranil, you should remember that along with a decrease in depression and enhanced activity, it can increase uneasiness, motor anxiety, hallucinations, and delusions. Patients can suffer from headaches, dizziness, palpitations, dry mouth, accommodation disorder, and urinary retention. Overdose can cause excitement (up to the development of a delirious state), insomnia, allergic reactions, and cardiac arrhythmia.