Treatment of patients with urogenital trichomoniasis using Metronidazole

According to the World Health Organization (WHO), about 200 million people get trichomoniasis every year. That is, the number of new cases per year is four times the population of a country like Australia. Trichomoniasis is considered the most common protozoal disease of the inhabitants of the temperate climate zone.

According to various estimates, the prevalence of trichomoniasis among women ranges from 5–30% depending on the population examined. 10% of all infectious diseases in men falls on trichomoniasis.

The poor epidemiological situation of trichomoniasis is due to two factors:

• 1) intensive migration processes and social conditions conducive to casual sexual contacts;
• 2) widespread contraception (women using IUDs are more likely to get sick).

The problems of treating trichomoniasis

The difficulty of treating trichomoniasis is attributed to the specific properties of the pathogen. The unicellular parasitic organism (trichomonas) can be classified as an anaerobic type of metabolism, which distinguishes Trichomonas from host cells and makes them vulnerable to the drugs of the 5-nitroimidazole group. In addition to this feature, these parasites are characterized by a transition from dichotomous division to intensive multiple division under the influence of unfavorable environmental factors, which is often manifested by a sharp increase in the richness of trichomonads of secrets at the beginning of treatment. Trichomonas protect against host cellular immunity factors by masking host plasma proteins through fixing antitrypsin on its surface.

Summarizing our own experience, and dermatovenerologists all over the world shows that for more successful treatment of trichomoniasis, the following provisions must be observed:

• all sexual partners should be treated at the same time, even in the absence of clinical and laboratory signs of disease;
• alcohol consumption and sex life during the treatment are excluded;
• the treatment regimen is determined to take into account the associated somatic diseases, as well as the age and weight of the patient;
• tactics of treatment depend on the form of the disease (acute or chronic process), localization of the inflammatory process and the presence of a mixed infection, as well as data from clinical and laboratory examination of patients.

The drugs of 5-nitroimidazoles group

Preparations of the group of 5-nitroimidazoles penetrate into trichomonas through both passive and active transport, selectively accumulating in the cell. Intermediate products of biological reduction of the nitro group also have trichomoniasis effects, which is partly due to irreversible inhibition of DNA synthesis.

Drugs of this group have been known for many decades. Their era began with Metronidazole, whose creation accomplished a real revolution in its time. However, today, the curability of patients with trichomoniasis using Metronidazole has decreased to 9%. Such a low efficiency is due to the patient's reinfection, the inaccessibility of all microfoci of infection in the body of patients, background diseases and, first of all, the widespread metronidazole-resistant strains of Trichomonas.

Resistance arises as a result of changes in the ultrastructure of Trichomonas, namely: single-membrane organelles are clothed with another membrane or included in the composition of the reticular system. Under these conditions, a drug that has an increased ability to penetrate through the biological membranes or destroy them will be effective.

Undoubtedly, the best drug for both the doctor and the patient is one that allows you to cope with several problems at once. Flagyl is exactly such a drug.

Metronidazole effectiveness in the treatment of trichomoniasis

Metronidazole in its composition is a derivative of 5-nitroimidazole, which has both antiprotozoal and antibacterial action. The relevance of this drug in the fight against such simple as Trichomonas (Trichomonas vaginalis) is confirmed by the recommendations of the Center for Disease Control and Prevention of the United States, according to which Metrodinazole is the first choice in the treatment of trichomoniasis, as well as bacterial vaginosis. According to research results, the insensitivity of T. vaginalis (the causative agent of trichomoniasis) to Metrodinazole was registered in only 2–5% of cases of this disease in the USA.

This is especially important given the high prevalence of trichomoniasis throughout the world, as well as the relationship of this disease with other sexually transmitted infections. In particular, according to modern concepts, trichomonas infection increases susceptibility to herpes viruses, human papillomavirus infection, and HIV.

Metronidazole is quickly and almost completely absorbed from the digestive tract when administered and distributed in many tissues and organs, as well as biological fluids (bile, cerebrospinal fluid, saliva, seminal fluid, vaginal secretions, and breast milk). Flagyl / Metronidazole and its metabolites are excreted mainly by the kidneys (60–80%), and partially with feces.

How to take Flagyl

It is important to remember that with trichomoniasis, a course of treatment that lasts 10 days should be carried out by both sexual partners at the same time. With care for your convenience, Flagyl pills are released in two formats: 250 mg oral pills and 500 mg vaginal pills.

The spectrum of action of generic Flagyl covers the simplest Lamblia intestinalis and Entamoeba hystolytica, so that it can be used to treat giardiasis and amebiasis (duration of treatment course is 5-10 days). If necessary, the treatment of protozoan infections with Flagyl online can be repeated after 4-6 weeks.

The benefits of Flagyl

An important advantage of cheap Flagyl is its efficacy (strong bactericidal action) against anaerobic bacteria and Flagyl price. Another aspect of drug use is its inclusion in the schemes of anti-helicobacter therapy of gastric or duodenal ulcer. Thus, Flagyl without prescription is included in the combined antibiotic therapy for the purpose of eradication of Helicobacter pylori.

The main contraindications to buy Flagyl are hypersensitivity to Metronidazole, the first trimester of pregnancy and breastfeeding.

It is important to note that for the convenience of specialists, the name of the active substance (Metronidazole) is indicated on the packaging of generic Flagyl, which makes it easier to work with it. The authenticity of the packaging is reliably protected with the use of modern technologies.

Remember! Treatment should not be limited to choosing the drug by the name of the disease when this requires knowledge, decision-making skills, and experience of a specialist.